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1,5-Benzothiazepine: Bioactivity and targets

Rajneesh Kaur, Raman Singh, Kuldeep Singh


1,5-Benzothiazepine nucleus is present in a number of clinically used drugs such as diltiazem, clentiazem, thiazesim, quetiapine, and clothiapine. 1,5-Benzothiazepine can be easily introduced in the molecule having 2-aminothiophenol moiety. This article considers various targets for 1,5-benzothiazepine nucleus to establish structural activity relationship. It is an attempt to compile account of various structural modification in 1,5-benzothiazepine scaffold as reported for their versatile biological activities. This review would provide a platforms for selection of suitable moieties and development of specific chemical entities with desired features.


1,5-benzothiazepine; Vasodilator; Antiplatelet aggregation; Anticholinesterase inhibitor; Glycogen synthase; kinase-3β inhibitors; Mitogen-Activated Protein kinase protein inhibitors

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ISSN 2347–9825

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