drugs and male infertility

Antioxidants, anti-inflammatory drugs and antibiotics in the treatment of reproductive tract infections and their association with male infertility

Emmanuel Izuka, Ifeanyi Menuba, Pallav Sengupta, Sulagna Dutta, Uchenna Nwagha

Abstract


Male infertility is a multifactorial condition which in some cases are presented with unidentifiable underlying causes. Men with idiopathic or noncurable oligoasthenoteratozoospermia as well as with unexplained infertility may be provided with non-hormonal medical treatment which includes the use of anti-inflammatory, antioxidants, fibrinolytic compounds, vitamin supplementation, and oligo-elements, presuming that most of these cases are possibly caused by inflammation and/or oxidative stress. In the case of the known pathogenic mechanisms responsible for male infertility, the treatments include specific antibiotics targeting the exact pathogenic strains, anti-inflammatory drugs targeting particular infections, as well as the use of antioxidants, singly or in combinations to ameliorate the detected oxidative stress. Combined non-hormonal therapies have also shown to improve semen quality. Since there is a lack of consensus regarding the exact dose, duration and effects of non-hormonal treatment on male infertility, this review article aims to present a comprehensive summary of how antioxidants, anti-inflammatory drugs and antibiotics treatment in reproductive tract infections are associated with amelioration of male fertility parameters.


Keywords


antibiotics; anti-inflammatory; antioxidants; male infertility; semen quality

Full Text:

PDF




ISSN 2347–9825

Authors/visitors are advised to use Firefox browser for better experience of journal site.

Open Access: Researcher from developing/low economy countries can access the jorunal contents through WHO-HINARI .