Synthesis of dihydropyrimidines

Synthetic studies on biologically novel pyrimidinones and related heterocyclic compounds

G B Dharma Rao, M.P. Kaushik


The thesis is constructed in four different parts. The first part describes the Yb(OTf)3 catalyzed/greener protocol for the synthesis of  β-ketoesters  via transesterification reaction and its applications.  The second part deals with   synthesis of pyrimidinones and pyrimidines derivatives using N-halo reagent [N,N'-dichlorobis(2,4,6-trichlorophenyl)urea] via Biginelli reaction. A five-component reaction involving transesterification/Biginelli/click reaction for the construction of glycoside annulated dihydropyrimidinone derivatives with 1,2,3-triazole linkage analogues was discussed in third part. Finally the fourth fraction engages with ZnO nanoparticles as a heterogeneous catalyst for the synthesis of naphthoxazinone derivatives through Biginelli like reaction.


Biginelli Reacion; Pyrimidinones; Pyrimidines; Transesterificaion; β-Ketoesters; ZnO-Nanoparticles; Naphthoxazinones; Click Chemistry

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ISSN 2347 – 8853

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