Synthesis, spectral, antimicrobial and antiandrogenic studies of main group metal complexes with biologically potent benzothiazoline

Abstract

New antibacterial and antifungal Schiff's base derived from substituted benzothiazoline (N^ÇSH), as well as its main group metal complexes incorporating antimony(III), bismuth(III) and arsenic(III) were synthesized with conventional as well as microwave irradiation method, characterized and screened for their in-vitro antibacterial as well as antifungal activity against Gram-negative (Escherichia coli), Gram-positive (Staphylococcus aureous) microbial strains and Fusarium oxysporum and Aspergillus niger fungal strains. The metal complexes show more antimicrobial potency as compared to the uncomplexed Schiffs' base. The ligand and its BiCl(N^ÇS)₂ and PhAs(N^ÇS)₂ compounds have been screened in vivo in male albino rats to test their antifertility property and results indicated that the administration of aforesaid compounds in male rats brought about an interference with spermatogenesis which ultimately caused infertility