Synthesis of novel Imidazo [1,2-b] pyridazine derivatives and study of their biomedicinal efficacy

Abstract

Novel 2-Substituted aryl (or alkyl)-6-(substituted aryl) imidazo[1,2-b]pyridazine derivatives have been synthesized by the suzuki reaction of 6-chloro-2-substituted aryl(or alkyl) imidazo[1,2-b]pyridazine  [obtained by the reaction of 3-amino-6-chloro pyridazine with 2-bromo-1-substituted aryl (or alkyl) ethanone] with substituted aryl boronic acid in presence of  bis(triphenylphosphine)palladium(ii) chloride and potassium carbonate in dimethyl formamide. These were screened for in-vitro antimicrobial activity against two gram positive (Streptococcus pyogenes and Staphylococcus aureus ) and two gram negative bacteria (Pseudomonas aeruginosa and Escherichia coli) as well as for antifungal and antimalarial activity against Plasmodium falciparum strain. Compound 2f and 2g exhibited good antimicrobial and antimalarial activity.