Synthesis, spectral studies and biological activity of novel 2-(substituted phenyl)-6-phenylimidazo[2,1-b]1,3,4-oxadiazole

Abstract

Diverse series of 2-(substitutedphenyl)-6-phenylimidazo[2,1-b]1,3,4-oxadiazole were synthesized. Five of the synthesized compounds were evaluated for their anticancer activity on MCF-7 cancer cell lines. The recently synthesized compounds were illustrated by IR, ¹HNMR. The anticancer activity of the compounds was carried out at Anti-Cancer Drug Screening Facility (ACDSF), Advanced Centre for Treatment, Research & Education in Cancer (ACTREC),Tata Memorial Centre, Kharghar, Navi Mumbai. The anticancer activity would be evaluated by In vitro testing using SRB assay protocols.All the screened compounds showed good to moderate activity against MCF-7 cancer cell line. Compound 5b, 6c, 7a were found to be active with GI₅₀ <10 µg/ml.All the synthesized compounds were screened against Gram Positive and Gram Negative bacteria Streptococcus aureus, Bacillus subtilisand E.coli respectively.