Tailoring methodologies for the architecture of organometallic frameworks of Bi(V) derived from antibiotics: Spectral, MS, XRPD and molecular modeling with antifungal effectiveness

Rajiv Kumar, Rajni Johar, Anil Krishan Aggarwal

Abstract


This communication describes formulation and designing methodology to discover architectural features of organometallic frameworks (OMFs) derived from the mixer of antibiotics drugs [L1 and L2] and Bi(V). Ligand (L1) was the mixer of two antibiotic drugs i.e. 5-(2,4-diguanidino-3,5,6-trihydroxy-cyclohexoxy)-4-[4,5-dihydroxy-6(hydroxymethyl)-3-methylamin-tetrahydropya-2-yl]oxy-3-hydroxy-2-methyltetrahydrofuran-3carbaldehyde and 2-(amino-hydroxymethylidene)-4-dimethylamino-6,10,11,12-tetrahydroxy-6-methyl-4,4a,5,5-atetrahydro-tetracene-1,3,12-trione. Another ligand, (L2), was the mixture of two antibiotic drugs (6R)-6-(a-phenyl-D-glycylamino) penicillanic acid and its hydroxyl derivative. Effective encapsulation between ligands and metal ion was highly dependable on fragmentation constraints of ligands and reactivity of Bi(V). The formation of OMFs was verified by various physiochemical and spectroscopical investigations i.e. elemental analysis, electronic, IR, 1H-NMR, 13C-NMR, mass spectroscopy, molecular modeling and XRPD patterns analysis. OMFs were highly capable to achieve pharmacophore geometries. Stability of OMFs was differed because of the variation of architectural features of concerned ligands which were not readily and rapidly tailored and achieved by any means. OMFs were screened extensively in-vitro against a number of pathogens i.e. Candida albicans, Aspergillus flavis and Candida glaberata which were responsible for various diseases. Results obtained revealed that OMFs have comparatively much higher antifungal activity than ligands.

Keywords


Organic metal frameworks (OMFs); Antibiotic drugs; Bismuth(V); Pharmacophore geometry; Antifungal Activity

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