Hyaluronic acid production

Optimization of extraction and production methods of Hyaluronic Acid (HA) from Streptococcus zooepidemicus

Surajit Baksi, Mukandar Khan, Mamta Panchal, Nirav Rao


Hyaluronic acid (HA) is a biopolysacharride present in connective tissues of body. It has high significant economic concern due to its high use in medical, cosmetic and food industries. It is present in several resources like rooster combs, eye and umbilical cord. Due to its good chemical and physical properties, it is used in ophthalmic and osteoarthritic surgeries. Presently, it is produced from animal and bacterial sources. But, the percentage yield is very less at large scale. In present study, effort was done to increase yield of HA from Streptococcus zooepidemicus, through modification of the fermentation and extraction process. The cell concentration and HA concentration was measured which showed that HA concentration increased with induced pH stress.


Hyaluronic acid; Production; Bacteria; Extraction

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