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Screenings of antimicrobial, cytotoxic and anti-inflammatory potentials of crude methanolic extracts of Crinum latifolium (Leaves)

Md. Saddam Hussain, Md. Abdur Rahman, Md. Shalahuddin Millat, Mithun Chandra Roy, Mohammad Tohidul Amin, Md. Mizanur Rahman Moghal

Abstract


Crude methanolic extract of Crinum latifolium plant (Leaves) was assayed to identify various pharmacological properties. Antimicrobial potential of crude methanolic extracts of Crinum latifolium was accomplished by most commonly used disc diffusion method against a wide range of Gram positive and Gram negative bacteria. Extracts showed slight antimicrobial activity against Gram positive bacteria while surprisingly showed significant antimicrobial activity against Gram negative bacteria E. coli. In contrast to Vincristine Sulphate, the crude metanolic, n-hexane soluble, petroleum ether soluble and chloroform soluble extracts showed slight to moderate cytotoxic properties with LC50 value of 7.06µg/ml, 48.978µg/ml, 242.83µg/ml and 153.93µg/ml respectively. Plant extract showed significant anti-inflammatory properties i.e 16.21% & 20.55%10mg/ml for hypotonic solution and heat induced condition respectively. So, this plant extract demands further research for revealing all its potency to have new safe drug for the entire respective field of medical science.


Keywords


Crinum latifolium; Zone of inhibition; Brine shrimp lethality bioassay; anti-inflammatory;

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