Ecology of supramolecular entities of antibiotics (SMEAs), on-demand controlled guest capture and release systems: tuning spacer and polarities in abiotic and biotic factors

Abstract

Earlier reported supramolecular entities of antibiotics (SMEAs) synthesized from various antibiotic drugs were tested to find out their antimicrobial properties i.e. Antibacterial activity against Escherichia coli, Bacillus subtilis, and Pseudomonas aeruginosa), and Antifungal activity against Candida albicans, Aspergillus flavis and Candida glaberata), and showed varying degree of percentage inhibition. Antibiotics medications no longer respond to antifungal and antibacterial infections, proposed SMEAs designed to get rid of it. The anti-fungal activity experiments are difficult due to slow growth of fungi and resemblance to host activity. The SMEAs assimilation through molecular mechanisms on microbes was explored through computational models and found suitable as potential antimicrobial agents against different microbes. The assimilation properties are dependent on their good adsorptive ability and that’s because of the interactions that occurred between microbial and backbones of SMEAs.