New reagent for attachment of cobaltacarborane clusters to biomolecules

Abstract

A novel boron reagent for click-labeling biomolecules [8-HC≡CCH₂OC₆H₄O(CH₂CH₂O)₂-3,3’-Co(1,2-C₂B₉H₁₀)(1’,2’-C₂B₉H₁₁)]^- has been prepared by the ring disclosure of the cyclic oxonium derivative of cobalt bis(dicarbollide) with hydroquinone monopropargyl ether. In the presence of Cu(I) catalyst the obtained alkyne reacts with organic azides forming 1,4-derivatives of 1,2,3-triazole as the 1,3-dipolar cycloaddition products. The products obtained were characterized by the methods of multinuclear NMR spectroscopy and mass-spectrometry.