Synthetic applications of Lithium Diisopropylamide (LDA) - A brief review

Harpreet Kaur, Avanish Arora, Mayank Kinger


LDA is a hindered non-nucleophilic base. It abstracts hydrogen from less hindered site as compared to other bases. LDA prefers the formation of thermodynamically favoured product compared to other bases. LDA is a region-selective reagent. It has wide applications in organic synthesis. This review is focused on the synthesis and applications of LDA in organic synthesis. 


LDA; hindered Base; nonnucleophilic base

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