cobaltacarborane clusters attachement

New reagent for attachment of cobaltacarborane clusters to biomolecules

Akim V. Shmal’ko, Igor B. Sivaev, Vladimir I. Bregadze, Leonid V. Kovalenko

Abstract


A novel boron reagent for click-labeling biomolecules [8-HC≡CCH2OC6H4O(CH2CH2O)2-3,3’-Co(1,2-C2B9H10)(1’,2’-C2B9H11)]- has been prepared by the ring disclosure of the cyclic oxonium derivative of cobalt bis(dicarbollide) with hydroquinone monopropargyl ether. In the presence of Cu(I) catalyst the obtained alkyne reacts with organic azides forming 1,4-derivatives of 1,2,3-triazole as the 1,3-dipolar cycloaddition products. The products obtained were characterized by the methods of multinuclear NMR spectroscopy and mass-spectrometry.

Keywords


cobalt bis(dicarbollide); oxonium ring disclosure; acetylene; 1,3-dipolar cycloaddition

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