Open Access Open Access  Restricted Access Subscription Access
pH sensitive linker

An economic and efficient synthesis of acid-labile glycerol based β-thiopropionate esters for potential application in drug delivery

Pooja Kumari, Monika Gulia, Shilpi Gupta, Devender Singh, Sumit Kumar


Acid labile linkers have been used widely for various biomedical applications with preferential applications in drug delivery. In this report, we have synthesized, glycerol based β-thiopropionate esters having an acid-labile β-thiopropionate linker with Michael addition reaction between hydrophobic thiol and hydrophilic tri-glycerol diacrylate. The solvent free reaction and purification by simply solvent extraction instead of any sophisticated chromatographic techniques provide an upper edge for their application in biomedical or other fields. These β-thiopropionate esters can potentially be used for the delivery and release of hydrophobic drugs at acidic sites particularly in cancer cells.


β-thiopropionate; Acid-labile surfactant; pH-sensitive; Michael addition reaction

Full Text:


ISSN 2347–9825

Authors/visitors are advised to use Firefox browser for better experience of journal site.

Open Access: Researcher from developing/low economy countries can access the jorunal contents through WHO-HINARI .